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10.1038/s41386-019-0486-5 11

Table of Contents What Cagrilintide and Retatrutide Are and How They Work Approved Uses and Current Clinical Evidence in the UK How These Medicines May Affect Men Specifically Dosage, Administration, and What to Expect Side Effects, Risks, and Safety Considerations Availability on the NHS and Next Steps for Treatment Scientific References Frequently Asked Questions What Cagrilintide and Retatrutide Are and How They Work Cagrilintide is a long-acting amylin analogue that promotes satiety and slows gastric emptying, while retatrutide is a triple agonist targeting GLP-1, GIP, and glucagon receptors to reduce appetite, enhance insulin secretion, and increase energy expenditure

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And class II HDACs include two subgroups: class IIa and class IIb

Importantly, in most CVOTs the combined use of the two drug classes was not a prespecified endpoint