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Biomarker studies: establishing senescent cell burden diagnostic (e.g., imaging, blood markers) to monitor effect and guide dosing

The cortisol response to food is also enhanced in obese subjects compared to normal BMI individuals (222)

optimum level For B12 testing, one of the big problems is that we measure the B12 in blood, but we need it in the cells, and most of all in the brain

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The longer-term picture is timing-dependent, since started near menopause it appears cognitively safe and may track with lower dementia risk, and the FDA removed the boxed warning, including the probable-dementia language, in 2026