is semaglutide still in short supply Hims & Hers stock falls 25% as FDA curtails compounded GLP-1s Type 2 diabetes: New Ozempic

Phase 3b open-label design, 751 adults with obesity but without T2D, randomized 1:1 to max tolerated dose of tirzepatide (10 or 15 mg) or max tolerated dose of semaglutide (1.7 or 2.4 mg) for 72 weeks, both on top of behavioral support

While the weight loss associated with GLP-1 drugs drives many of the health benefits, there is also a direct drug effect independent of weight loss

Inhibition of inflammation and iNOS improves lymphatic function in obesity

GLP-1 therapy isnt for everyone with RA

Below is the receptor-level breakdown for working researchers strictly receptor pharmacology, no outcome claims

"REVERSING AGING: PREVENTING AGE-RELATED DECLINE IN GLUTATHIONE AND MITOCHONDRIAL FUNCTION INCREASES LONGEVITY." Innovation in Aging