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[DOI] [PubMed] [Google Scholar] Prvost M, Vertongen P, Raussens V, Roberts DJ, Cnuddle J, Perret J, et al

In the past, doctors relied on their own knowledge of bones, joints and tendons to direct the needle

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The two of them first met by chance at a meeting organised by the Medical Research Society when Samols was hunting for someone to help with his venture

In addition to the more traditionally characterized EECs that secrete gut peptides, recent studies have discovered the presence of specialized EECs with long cytoplasmic processes on the basal side that directly signal primary afferent neurons innervating the gut 95

In the case of alcohol the mechanism is well described: ethanol metabolism involving the CYP2E1 enzyme releases free radicals, and these reduce the level of reduced glutathione in the liver (Lieber, Drug Metabolism Reviews 2004, PMID 15554233)