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Israel, A

Pharmaceutical approaches for enhancing solubility and oral bioavailability of poorly soluble drugs

DOI: 10.1136/fn.88.6.f534 24

10.1016/S0168-8278(99)80291-8

These pathways include PI3K/Akt/mTOR (phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin), AMPK/SIRT1/NF-B (AMP-activated protein kinase/NAD-dependent deacetylase sirtuin-1/nuclear factor kappa B), and MAPK/AP-1 (mitogen-activated protein kinase/activator protein 1), which play role in many human pathologies like cancer, diabetes, neurodegenerative, and cardiovascular disorders [54,55,56,57]