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This initial phosphorylation cascade is followed by the phosphorylation of two other tyrosine residues (Y1349, Y1356), and these residues have been shown as docking sites for downstream signaling molecules that mediate Ras/Raf/MAPK, PI3K/AKT/mTOR, and/or STAT3/5 pathways [57]

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Glutaredoxins: glutathione-dependent redox enzymes with functions far beyond a simple thioredoxin backup system

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DOI: 10.1007/978-1-4684-5730-8_29 84