Its naturally produced in cells and concentrated in the liver, where it helps detoxify and protect against oxidative damage
GCL is a heterodimeric enzyme composed of a glutamate-cysteine ligase catalytic subunit (GCLC), which confers enzymatic activity, and a glutamate-cysteine ligase modifier subunit (GCLM), which enhances GCLC efficiency and attenuates feedback inhibition by GSH
However, the effect of glutamate on cataracts remains unclear, as subcutaneous administration of monosodium L-glutamate to newborn mice induces cataracts 29
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The peptide's research profile has expanded from its origins in gastrointestinal cytoprotection, first described by Sikiric et al., to a broad range of tissue repair applications
This multi-pathway approach is exciting from a therapeutic standpoint its like orchestrating an overall healing response rather than targeting one single receptor
