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In turn, miR-214 targets and regulates the Unc-51-like autophagy activating kinase 1(ULK1), which hinders the initiation process of autophagy, leading to impaired autophagy in PTEC and thereby affecting the repair capacity of renal tissue (Ma et al., 2020

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10.1016/j.mito.2016.06.006 111

If malignant melanoma is found, it is reasonable to stop the TNF inhibitor