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Produces b-ions and y-ions Provides amino acid sequence information Enables localization of modifications Key Insight: Optimized fragmentation conditions are critical for complete sequence coverage

To determine dose level and dose frequency of central administration of mGIPR-Ab, pharmacokinetic profile of ( a ) brain and ( b ) plasma exposure was assessed at 4, 24, 72, 120, and 168 h following a single ICV injection of 15 g/L/mouse dose of mGIPR-Ab

For short-term storage, which generally refers to periods of a few days to several weeks, refrigeration at 28C is often sufficient

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