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AGA clinical practice guidelines on the gastrointestinal evaluation of iron deficiency anemia

Chronic colitis induces meninges traffic of gut-derived T cells, unbalances M1 and M2 microglia/macrophage and increases ischemic brain injury in mice

That is normal and expected

This immune response leads to inflammation in the joints, which can cause significant discomfort and, over time, may lead to joint damage and other complications