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Therefore, higher proinsulin levels in the thymus are hypothesized to induce negative selection of insulin-specific thymocytes, thereby increasing tolerance to insulin autoantigens (63, 64)

Given the poor bioavailability of oral NAD+ and its precursor vitamins through supplements (and why most wellness supplements have limited benefit), IV or subcutaneous routes are necessary to achieve the serum concentrations observed in the published research

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