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Esquema del funcionamiento GST-GSH para eliminar compuestos txicos (oxidados)

DPP-4 inhibition extends this half-life and increases circulating active GLP-1 by approximately 2- to 3-fold, which is sufficient to engage high-density pancreatic islet receptors and produce glucose-dependent insulin secretion and glucagon suppression

However, oral semaglutide and other GLP-1 RA drugs act by increasing insulin secretion, inhibiting glucagon secretion that leads to reduced hepatic glucose production, correcting defects in the production of gastrointestinal incretins, and promoting an effect on the central nervous system that leads to appetite suppression and weight loss, which is reflected in increased muscle and liver sensitivity to insulin [67, 68]

G.ReidesC.EvelsonP.KohanS.LustigE

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Effect of dulaglutide on cognitive impairment in type 2 diabetes: An exploratory analysis of the REWIND trial