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Thus, many H2AX + cells were observed in the Achilles tendon of rats administered pefloxacin, which was mitigated by dexamethasone co-treatment

EULAR Abstract, Madrid (2017)

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Hepatic cytochrome P450 isoenzymes CYP1A2 and CYP3A4 mediate N-de-ethylation, so polymorphisms or competitive inhibition at these pathways (e.g., by certain antidepressants or azole antifungals) may increase systemic exposure, underscoring the importance of individualizing dosage and monitoring serum concentrations in prolonged infusions

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Autonomic-immune-vascular interaction: an emerging concept for neurogenic hypertension