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Recent studies have suggested that GLP-1s may have direct effects on skin cells, opening up new possibilities for improving skin health and combating the signs of aging

The effect of Nuclear transcription factor kappa B (NF-B) on POMC expression is unclear

Although further investigation into the importance of the secretory pattern of GH in humans is needed, data strongly suggest that pulsatile secretion is required for some of the physiologic effects of GH

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Esposito C, Garzarella EU, Santarcangelo C, et al

While its dual GIP/GLP-1 agonism may marginally increase the frequency of these issues compared to other GLP-1 monotherapies, these events are mild and manageable