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In a 28-day Phase II clinical trial, emricasan administration significantly decreased the levels of caspase 3/7 and ALT levels, demonstrating a favorable safety profile and good tolerability [114]

A comprehensive literature search across multiple databases identified a total of 6,541 studies, retrieved from PubMed ( n = 848), Web of Science ( n = 1,015), Scopus ( n = 2,523), Embase ( n = 1,525), Cochrane ( n = 367), as well as Google Scholar and manual reference searches ( n = 263)

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The KEAP1-NRF2 system as a molecular target of cancer treatment

The limited sample size significantly hinders the interpretation of the results

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