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Continuous LEAP2 administration to calorie-restricted Ghsr -knockout mice induces weight loss, hypoglycaemia, reduced body temperature, and increased hepatic IL-6 and IL-1 mRNA expression, indicating that LEAP2 can modulate physiological processes beyond the ghrelin-GHSR system [214]

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It has been demonstrated that cinnamaldehyde and cinnamon treatment leads to downregulation of the NF-B pathway and reduces the levels of proinflammatory cytokines in diseases such as T2D and atherosclerosis in ApoE / mice [124, 125]