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Meta-analysis Meta-analysis was performed using the R statistical program, R version 4.4.2 (The R Foundation for Statistical Computing, Wirtschaftsuniversitt Wien, Vienna, Austria) (Sterne et al., 2016

PLoS ONE 6 , e21889 (2011)

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These factors motivate transcriptomic and proteomic profiling to detect unanticipated pathway activation, coupled with dose-window optimization to balance metabolic efficacy with system-level perturbations

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