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SARS-CoV-2 entry mechanism is mediated by the SPIKE protein (S protein) on the viral coat, which is comprised of two subunits: the S1 subunit containing the receptor binding domain (RBD) to ACE2, and the S2 subunit, responsible for membrane fusion

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In our translational work, we also reported a link between LAC levels, cellular aging and metabolic function in the antidepressant responses to the insulin-sensitizing agent pioglitazone, an agent for treatment of diabetes type 2 and tested as potential antidepressant [60]