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Bae JW, et al

2 There is also a much-discussed link to the Wnt/-catenin pathway, which is a genuine master regulator of the hair cycle: active -catenin signaling in the dermal papilla drives follicles into anagen and enhances their hair-inducing capacity, while reduced signaling is associated with regression and miniaturization

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Specifically, it is obvious that the newly formed Arg123-Glu40 salt bridge is due to the missense mutation L23B R (Figure 2), i.e., the substitutin of the leucine with a positively charged arginine at position 23 of semaglutides backbone (Figure 2)