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A mechanism of action phase 1 study showed that the glycemic efficacy of tirzepatide in T2DM results from concurrent improvements in key components of diabetes pathophysiology, including -cell function, insulin sensitivity, and glucagon secretion (135)

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However, everyone's body is different, so if you notice any changes in your sleep patterns, try shifting your dose to the morning

This is particularly important for patients experiencing cardiovascular deconditioning as a result of prolonged bed rest or severe exercise intolerance

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