Protein Cell 7 , 325337 (2016) Cherezov, V
See also: Medicare coverage of cardiovascular medications and the ACCESS model
The most significant changes accumulate between months four and twelve, with continued but gradually slowing progress through the full 72-week treatment period
In Phase 3 SURMOUNT trials, Retatrutide achieved unprecedented 24.2% mean weight loss at the 12mg dose over 48 weeks, with 91% of participants achieving 15% body weight reduction
According to Lilly, retatrutide is not yet available to the public, is not FDA-approved, and is still being studied in Phase 3 trials
However, some studies suggest that, after about 1 year, a number of people who stop taking a GLP-1 may regain as much as 60% of the weight they had lost while on the drug