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Compared to oral administration, rectal delivery achieves higher effective drug exposure at the lesion site while reducing systemic distribution, thus lowering the risk of potential systemic side effects

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If methylation is sluggish (often for genetic reasons) or the body doesn't have enough nutrients (including vitamin B12 and folate) to turn the methylation cycle, the body can't make enough glutathione

J Pineal Res 34:4052 Jaworek J, Nawrot K, Konturek SJ, Leja-Szpak A, Thor P, Pawlik WW (2004) Melatonin and its precursor, L-tryptophan: influence on pancreatic amylase secretion in vivo and in vitro