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MT-1's 33-minute serum half-life means the acute overdose clears rapidly, but the melanocortin receptors remain activated for 1218 hours post-injection

All evidence comes from mouse models and cell cultures

Oxidation alters the peptide structure and reduces receptor binding affinity

for instance: tumor-associated macrophages (TAMs) show increased levels of the scavenger receptor CD36, leading to accumulated intracellular lipid and elevated fatty acid oxidation (FAO), which in return contributes to pro-tumor TAM polarization (Su et al., 2020)

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This concept also applies for the treatment of obesity. She added that the root cause of obesity is complex and heterogeneous