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Abstract Flavonoids are a vital class of dietary polyphenolic compounds that have attracted considerable attention owing to their powerful immunoregulatory and anti-inflammatory effects

For instance, administering IGF-1R mAbs in cancer trials was reported to result in increased adverse events in younger populations 34 , including insulin resistance, possibly due in part to disruption of the somatotropic axis and associated deleterious effects of excess GH 41,42

doi: 10.1111/apa.14910 81 LuCLChangYHSunYLiCY