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They frequently induce gastric irritation, bleeding disorders, and kidney strain with chronic or high-dose use

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The SSRI, which inhibit serotonin transporter SERT/SLC6A4 (expressed in both neurones and astroglia) and thus increase bioavailability of serotonin, are probably the most widely used in the treatment of depression

doi: 10.1039/D3LC00994G 119 MencattiniAMatteiFSchiavoniGGerardinoABusinaroLDi NataleCet al

Research outcomes should not be extrapolated to expected human results

The absence of a Drug Affinity Complex permits investigation of shorter-duration signaling patterns and pulsatile receptor activation within controlled experimental systems