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Retatrutide achieved 24% loss in 48 weeks while semaglutide achieved 17% in 68 weeks and tirzepatide achieved 22% in 72 weeks

It is FDA-approved for reducing visceral fat in people with HIV-associated lipodystrophy, but it is sometimes discussed in muscle-building circles due to its ability to increase GH and IGF-1 levels

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Glucagon like peptide-1 attenuates bleomycin-induced pulmonary fibrosis, involving the inactivation of NF-kappaB in mice

This approach substantially reduced insulin resistance, promoted glucose uptake, and lowered blood glucose levels by activating the IRS1/PI3K/AKT signaling pathway (Min et al., 2022)