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examined the nonclinical efficacy of MC4-NN20453 in lean rats ( MC4-NN20453 entered the clinic in 2010 to investigate safety, tolerability, and pharmacokinetic exposures in overweight and obese participants ( Table 2 ) ( Skin-related adverse events (AEs) were observed in both the SAD and MAD portions of the trial ( Participants on MC4-NN20453 also reported sexual arousal, albeit with low incidence (27%) ( Despite early termination of the trial, the pharmacokinetics of MC4-NN20453 were analyzed for 43 SAD subjects and 48 MAD subjects ( 1/2 values averaged between 234 and 274 hours with a plasma clearance of 0.0005 L/h/kg

Karimi H, Ranjbar Saraskanroud M, Balazadeh KF