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206 In addition, expression of the mitochondrial isoform of phosphoenolpyruvate carboxykinase, involved in gluconeogenesis from non-carbohydrate carbon substrates such as pyruvate, lactate, glycerol and glucogenic amino acids, was significantly increased, 499 indicating an elevated demand for free glucose through enhancing astrocytic glucose metabolism in GDI1 -null mice

The inflammation and demyelination that occurs in both WM and cortical lesions leads to axon injury and loss, which is considered to be the major factor leading to disability and cognitive deficits in MS (60, 61)

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