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This results in most patients being diagnosed at advanced stages, contributing to the poor prognosis and low five-year survival rate, making it known as the king of cancer. For patients with resectable PC, early surgical intervention followed by adjuvant therapy remains the preferred approach, offering potential cure [267]
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A fresh analysis of the clinical and financial implications of comprehensive coverage in Medicare of GLP-1s for all current FDA indications (type 2 diabetes, obesity, heart disease and metabolic-associated steatohepatitis) offers some hope for long-term cost savings
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Paradoxically, these senescent cells acquire a senescence-associated secretory phenotype (SASP) and release IL-6, which functions in a paracrine manner to stimulate the proliferation of neighboring PASMCs
