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Strategies to Overcome Semaglutide Tolerance and Plateaus The most straightforward approach is dose escalation

[18] showed that intravenous infusion of GLP-1 for 48 hours in animal models with induced dilated cardiomyopathy significantly improved LV contractility, stroke volume, and cardiac output

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Because the original research concerned the gut, PLIVA tested it in the bowel disease ulcerative colitis, given as an enema, in a randomized, placebo-controlled study [11]

Here's the realistic range