e , Top, volcano plot showing relative fold change (log 2 ) in ER-metabolite abundance versus log 10 (P value) from ER-tag HEK293T cells treated with thapsigargin compared to untreated
Only a small, yet significant amount is metabolised via the hepatic cytochrome P450 enzyme system (its CYP2E1 and CYP1A2 isoenzymes), which is responsible for the toxic effects of paracetamol due to a minor alkylating metabolite (N-acetyl-p-benzo-quinone imine, abbreviated as NAPQI).[17] There is a great deal of polymorphism in the P450 gene, and genetic polymorphisms in CYP2D6 have been studied extensively
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How long does it take for 5-amino-1mq to show measurable metabolic effects