See section 7 below for a discussion of agents presently under study for gout
A pilot study investigating changes in the human plasma and urine NAD+ metabolome during a 6-hour intravenous infusion of NAD+
Baptista ATA, Coldebella PF, Cardines PHF, Gomes RG, Vieira MF, Bergamasco R, et al
Common Side Effects When side effects occurred, they were typically mild, transient, and similar in frequency to placebo groups: Reported Adverse Effects Most Common (occurring in small percentage of participants): Mild to moderate headaches (most frequently reported, often resolving with continued use) Injection site reactions (minor redness, swelling, or irritation at injection site) Gastrointestinal effects (particularly at higher oral doses: mild nausea, diarrhea, flatulence) Fatigue (reported occasionally during initial adaptation period) Rare Events: One case of chest tightness was deemed possibly related to treatment in safety trials
Additionally, when succinyl-CoA is converted to succinate by succinate thiokinase, one molecule of GTP is generated, which can be readily converted to ATP by nucleoside-diphosphate kinase (NDPK)
Glutathione metabolism and its implications for health Jozefczak, M., et al
