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If you have any of the following conditions, you should not take Saxenda: Kidney disease Liver disease Family or personal history of medullary thyroid cancer Family or personal history of multiple endocrine neoplasia syndrome type 2 (MEN 2) Gastroparesis (chronic disorder of delayed stomach emptying) History of pancreatitis Pregnancy Breastfeeding How should I store Saxenda (liraglutide)
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It should be noted that physiologic GLP-1R agonism in the periphery mediates food intake reduction via vagal afferent signaling as rats with a surgical subdiaphragmatic vagal deafferentation (SDA) exhibit a more mild food intake suppression in response to acute administration of GLP-1 analogues than sham operated animals (80, 81)
Pharmacol Res Perspect 3:e00136 Pai V, Paneerselvam A, Mukhopadhyay S et al (2014) A multicenter, prospective, randomized, double-blind study to evaluate the safety and efficacy of Saroglitazar 2 and 4 mg compared to pioglitazone 45 mg in diabetic dyslipidemia (PRESS V)
The following is aggregated from user reports and extrapolated from preclinical data
