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Caught between a desire to be thin and strong urges to eat more food, weight suppression could trap people in cycles of bingeing and purging. WHY IT MATTERS The study highlights the concept of weight suppression the difference between a persons highest and current weight and how it affects hormone levels

Finally, to address potential pleiotropic effects, we excluded SNPs associated with other potential confounders identified through PhenoScanner ( Outcome sources To minimize potential bias due to population diversity, we restricted our drug target MR analysis to participants of European ancestry