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Figure 3 5.1 Mechanisms of action 5.1.1 Reduction of uremic toxins Impaired protein absorption in CKD patients causes an increase in levels of undigested or unabsorbed proteins entering the colon, creating conditions in the gut that promote the growth of proteolytic bacterial species (Bammens et al., 2003

Bosello-Travain V, Conrad M, Cozza G, Negro A, Quartesan S, Rossetto M et al (2013) Protein disulfide isomerase and glutathione are alternative substrates in the one Cys catalytic cycle of glutathione peroxidase 7

Stress, ageing, chronic disease, and our environment can all influence NAD+ levels

Individual 25 L qPCR reactions containing 2.5 L of a 1:5 gDNA dilution were performed with SYBR Select Master Mix (Thermo Fisher, cat

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Genetic factors, particularly variations in urate transporter genes, significantly influence individual susceptibility to hyperuricemia