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This response was characterized by the robust activation of catalase, ascorbate peroxidase, glutathione, and ascorbate, alongside profound metabolic reprogramming involving the accumulation of glycine, specific organic acids, and extensive remodeling of its fatty acid composition

15,23 GSH depletion in the brain is a common finding in patients with neurodegenerative conditions eg Alzheimers disease and Parkinsons disease, which can cause neurodegeneration prior to disease onset

Dubuc et al., 2004

GLP-1 influences insulin secretion and central appetite control, while amylin primarily modulates satiety and gastric emptying

Further evidence for methionine at the reactive center

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