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There is no known interaction between the two at the topical and oral levels

Cardiovascular disease Cardiovascular risk factors Nicotinic acid is a well-known lipid-lowering agent: Nicotinic acid therapy markedly increases high-density lipoprotein (HDL) cholesterol concentrations, decreases serum lipoprotein(a) concentrations, and shifts small, dense low-density lipoprotein (LDL) particles to large, buoyant LDL particles

10.1111/j.1699-0463.1990.tb05004.x 79

When paired with GLP-1 treatments, it helps refine body contours, enhance tone, and maintain long-term results