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Studies have investigated NNMT inhibition in the context of obesity, metabolic dysfunction, lipid accumulation, and energy-expenditure models, with research also exploring effects on adipocyte differentiation and methylation pathways
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[73] [74] [75] It is synthesized by some bacteria in the gut microbiota in humans and other animals, but it has long been thought that humans cannot absorb this as it is made in the colon, downstream from the small intestine, where the absorption of most nutrients occurs
These data suggest that 3-AR is crucial for mediating the full lipolytic effects of both compounds, particularly AOD9604
