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Glucagon can directly stimulate somatostatin secretion, independently of insulin Studies have demonstrated that glucagon plays a role in stimulating insulin secretion by a direct effect on glucagon and GLP-1 receptors expressed on the beta cells [12, 14, 17]

[3] The pharmacokinetics explain why this route stays local

Indeed, occlusion is more likely in smaller vessels versus larger ones, hindering sinusoidal distribution while increasing portal areas exposure, leading to immune clearance of transplanted hepatocytes

This therapy involves the transfer of gastrointestinal microbiota obtained from a healthy donor to the gastrointestinal tract of a recipient, i.e., a person with known dysbiosis [86]