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High or frequent dosing is the main concern, and people with kidney, liver or other conditions are most at risk

Generally well tolerated (32) (37) (42) (43) Headache, mild GI upset, flatulence, nausea, vomiting, diarrhea Patients with bipolar disorder may develop manic phase (11) (22) (37)

Regarding U-87MG, a clear separation of the exometabolome was observed in the PCA analysis comparing U-87MG cells transfected with the anti- GLS1 siRNA and the controls (control and lipofectamine) (Fig

Acta Med Iran

Moreover, there are concerns about the bioavailability of the iron used in fortified foods, particularly with elemental iron powders

As both neuroinflammation and oxidative stress or metabolic dysregulation are prevalent across the epilepsies, which are both argued to be causal and consequential to the disease, the direct interactions between neuroinflammation and oxidative stress are key components of disease pathology which deserve further evaluation