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Whilst all agents in this class can cause nausea, individual responses vary: Dulaglutide (Trulicity) is administered once weekly and some patients report fewer gastrointestinal effects Liraglutide (Victoza) requires daily injection but allows more gradual dose titration Exenatide (Byetta, Bydureon) is available in both short-acting (twice daily) and extended-release (once weekly) formulations Switching between GLP-1 agonists should be undertaken under medical supervision with appropriate dose adjustment and monitoring

A landmark 2023 cardiovascular outcomes trial demonstrated that semaglutide reduced major adverse cardiac events by 20%, sparking questions about whether this GLP-1 receptor agonist actively lowers cholesterol or simply works through other mechanisms

GLP-1s workbut even great therapies can hit a ceiling

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