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Donato, A

Tissue plasminogen activator (tPA), is a naturally produced protein in endothelial cells that functions as a serine protease, catalyzing the conversion of plasminogen to plasmin, which acts as a key player in fibrinolysis

However, in 1968, missing electron density was reported in the C-terminal residues of hemoglobin, suggesting the presence of flexibility or disorder in this region (Perutz et al., 1968)

Long-term risks unknown: Chronic use could have consequences that have not yet been documented

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Methionine and choline are generally more stable but can still be affected by prolonged heat exposure