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Continuous infusion of exendin-4 over 28 days reduced monocyte adhesion to the endothelium, downregulated aortic mRNA expression of intercellular adhesion molecule-1 (ICAM-1), and suppressed atherogenesis in Apoe / mice on HFD without affecting LDL-cholesterol (LDL-C) levels (6)

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34.9% of the placebo group at 104 weeks

Pfizer plans to conduct dose optimization studies in the second half of 2024 evaluating multiple doses of the preferred modified release formulation to inform the registration enabling studies

The Wegovy pill surfaces as the first and most prominently featured treatment option during the medication selection step, though branded pens and compounded semaglutide are available to choose from as well

doi: 10.1001/jama.2015.9676 123 Pi-SunyerXAstrupAFujiokaKGreenwayFHalpernAKrempfMet al