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When these mice where administered IGF-1 they showed lowered fasting glucose, and because no functional IGF-1R is present in muscle, such effect is believed to be due to renal gluconeogenesis suppression [129, 163]

1.3.1 Polymeric nanosystems Polymeric NPs may be functionalized and retained for months, and the physicochemical characteristics of these carriers could regulate drug release [89]

However, the actions of many of these other proteins vary depending on how the lysine contained in them is acted upon

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Zhao et al., 2021), however these experimental data are only obtained in animal models (Shaker et al., 2021)

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