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The rationale for combining them is based on the hypothesis that parallel modulation of nitric oxide signaling, cytoskeletal dynamics, extracellular matrix remodeling, and oxidative stress responses may generate additive or synergistic effects in controlled experimental models
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During the item generation and discussion and clarification phases, the experts identified 14 distinct challenges: costs, supply challenges, lack of evidence, polypharmacy, barriers to prescription, lack of knowledge, adherence concerns, aversion to injection therapy, clinical inertia, titration needs, perceived health state, fear of adverse effects, lack of clinical guideline recommendations, and lack of measurable outcomes to guide therapy
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5.4 Corpus cavernosum: erectile function and reproductive health Arthrospira platensis has shown promising effects on disorders involving the corpus cavernosum, particularly infertility and erectile dysfunction (ED), often-linked to metabolic conditions such as obesity