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These findings highlight the intricate interplay between mechanosensitive and heat-sensitive channels in the PNS and CNS, suggesting Piezo2 as a potential therapeutic target for visceral pain treatment

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BDNF supports the survival and function of sensory and motor neurons, and its deficiency contributes to nerve degeneration

With advances in mechanistic understanding and translational tools, ferroptosis is poised to become a promising therapeutic breakthrough in the precision treatment of Alzheimers disease

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Finally, intestinal disorders promote the pathological progression of AD by increasing amyloid plaque formation, neuroinflammation and IR (Vogt et al., 2018)