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Evaluation of a melanocortin-4 receptor (MC4R) agonist (Setmelanotide) in MC4R deficiency

Abstract Migraine severely impacts quality of life in children and adolescents and has been identified as the most important cause of neurological disability in youth

PI3K/AKT1 signaling pathway mediates Sinomenine-induced hepatocellular carcinoma cells apoptosis: an in vitro and in vivo study

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Taken together, mitophagy plays a dual role in iron-dependent cell death: under physiological states or the early stages of pathogenesis, including the development of oxidative stress, mitophagy degrades damaged mitochondria through negative feedback signaling, preventing ROS generation and hindering the initiation of iron-dependent cell death

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