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Notably, the myeloid-associated secretome of FerroCAFs overlapped with certain inflammatory CAF (iCAF) signatures, including the production of growth factors and cytokines such as Csf1, Ccl2, Ccl7, Il6, Cxcl1, and Cxcl2 , which collectively contributed to immunosuppression and tumor growth [59]
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Th17 cells UA has been discovered to directly foster Th17 differentiation
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