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Furthermore any consideration of the protective action of UA in the central nervous system needs to be seen in the light of its well-established contributary role in the development of peripheral cardiovascular and metabolic diseases 2,3

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Its simplicity and selectivity make it an intriguing candidate for localized anti-inflammatory research in gastrointestinal and dermatological models

At present, there are no treatments established to prevent cognitive decline in CKD patients, and the limited range of medications available for cognitive impairment only have moderate activity (Yiannopoulou et al., 2019)