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The tACE form is exclusive to the male germinal cells with an enzymatic activity critical for male fertility 294,295,296

The EU trial (n=74) showed median pain-free direct sunlight exposure of 6.0 hours versus 0.8 hours on placebo, with fewer phototoxic reactions (77 vs 146

It also has direct effects on glucose body function, tending to increase blood glucose through insulin antagonism

Consider regular monitoring of blood pressure, lipid panels (every 3-6 months), liver enzymes, HbA1c and fasting glucose, kidney function tests (eGFR and UACR), and hsCRP as an inflammatory marker

Early warning signs include persistent fatigue that does not improve with rest, difficulty concentrating or brain fog, tingling or numbness in hands and feet, weakness in the legs, dizziness when standing up, pale or yellowish skin, and a sore or swollen tongue

More information is available from the CDC here